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Recovery from spinal cord injury: A new transection model in the C57Bl/6 mouse
Author(s) -
Seitz Alexander,
Aglow Elsa,
HeberKatz Ellen
Publication year - 2002
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10098
Subject(s) - spinal cord , spinal cord injury , white matter , neuroscience , anatomy , medicine , cord , retrograde tracing , anterograde tracing , animal model , central nervous system , biology , surgery , magnetic resonance imaging , radiology
Spinal cord transections in mammalian animal models lead to loss of motor function. In this study, we show that functional recovery from complete transection of the adult mouse spinal cord can in fact occur without any intervention if dural injury along with displacement of the ends of the cut cord and fibroblastic infiltration is minimized. Underlying this function is the expression of GAP‐43 in axonal growth cones, axonal extension and bridging of the injury site indicated by biocytin retrograde tracing and neuronal remodeling of both the white matter and the gray matter. Such studies suggest a new murine model for the study of spinal cord regeneration. © 2002 Wiley‐Liss, Inc.