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Regulation of mRNA stability in the nervous system and beyond
Author(s) -
Malter James S.
Publication year - 2001
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.10021
Subject(s) - messenger rna , gene expression , gene , regulation of gene expression , biology , microbiology and biotechnology , central nervous system , function (biology) , peripheral nervous system , nonsense mediated decay , genetics , neuroscience , rna , rna splicing
The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence‐specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation. J. Neurosci. Res. 66:311–316, 2001. © 2001 Wiley‐Liss, Inc.