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Regulatory effect of m 6 A modification on different viruses
Author(s) -
Yu PeiLun,
Cao SanJie,
Wu Rui,
Zhao Qin,
Yan QiGui
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.27246
Subject(s) - rna , demethylase , biology , viral replication , virus , virology , methyltransferase , microbiology and biotechnology , chemistry , genetics , gene , methylation , epigenetics
N 6 ‐methyladenosine (m 6 A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m 6 A modification. In different kinds of viruses, m 6 A modification has two completely opposite regulatory functions. This paper reviews the regulatory effects of m 6 A modification on different viruses and provides a reference for studying the regulatory effects of RNA epitranscriptomic modification.