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Emergence of a young case infected with avian influenza A (H5N6) in Anhui Province, East China during the COVID‐19 pandemic
Author(s) -
Yu JunLing,
Hou Sai,
Feng YaTing,
Bu Ge,
Chen QingQing,
Meng ZhaoQian,
Ding ZhenTao,
Guo LiangZi,
Zhou Xue,
Wang Meng,
Huang XinEr,
Li WeiWei,
He Lan,
Gong Lei,
Sun Yong,
Xu Zhiwei,
Pan HaiFeng,
He Jun,
Wu JiaBing
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.27179
Subject(s) - reassortment , virology , influenza a virus subtype h5n1 , neuraminidase , pandemic , context (archaeology) , biology , virus , h5n1 genetic structure , hemagglutinin (influenza) , antigenic shift , antigenic drift , covid-19 , medicine , disease , infectious disease (medical specialty) , paleontology , pathology
In the context of the coronavirus disease 2019 pandemic, we investigated the epidemiological and clinical characteristics of a young patient infected by avian influenza A (H5N6) virus in Anhui Province, East China, and analyzed genomic features of the pathogen in 2020. Through the cross‐sectional investigation of external environment monitoring (December 29–31, 2020), 1909 samples were collected from Fuyang City. It was found that the positive rate of H5N6 was higher than other areas obviously in Tianma poultry market, where the case appeared. In addition, dual coinfections were detected with a 0.057% polymerase chain reaction positive rate the surveillance years. The virus was the clade 2.3.4.4, which was most likely formed by genetic reassortment between H5N6 and H9N2 viruses. This study found that the evolution rates of the hemagglutinin and neuraminidase genes of the virus were higher than those of common seasonal influenza viruses. The virus was still highly pathogenic to poultry and had a preference for avian receptor binding.

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