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Association of IL‐32 rs28372698 polymorphism with active chronic HBV infection
Author(s) -
Zheng Shuo,
Li Mei,
Pan Xingfei,
Huang Xiaoping
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.27140
Subject(s) - virology , biology , medicine , immunology
Interleukin‐32 (IL‐32), a multiple proinflammatory cytokine, plays a vital role in immune‐related diseases and infectious diseases. The promoter region of IL‐32, which showed functional polymorphism, could regulate IL‐32 expression. Although IL‐32 rs28372698 polymorphism has been related to a lot of inflammatory diseases, the association of IL‐32 rs28372698 polymorphism with a hepatic flare of chronic HBV infection has not been reported. In the present study, IL‐32 rs28372698 polymorphism was genotyped in 104 chronic HBV carriers and 151 active chronic hepatitis B (CHB) patients. The frequency of IL‐32 T/T genotype in patients with active CHB was significantly higher than that in chronic HBV carriers. Furthermore, the frequency of the T allele at IL‐32 rs28372698 in active CHB patients was also higher than that in chronic HBV carriers. The serum level of IL‐32 in active CHB patients was higher than that in chronic HBV carriers. Our results imply that IL‐32 T/T polymorphism might be associated with a hepatic flare of chronic HBV infection.