Premium
Prolonged presence of replication‐competent SARS‐CoV‐2 in mildly symptomatic individuals: A report of two cases
Author(s) -
Mendes Correa Maria C.,
Leal Fabio E.,
Villas Boas Lucy S.,
Witkin Steven S.,
Paula Anderson,
Tozetto Mendonza Tania R.,
Ferreira Noely E.,
Curty Gislaine,
Carvalho Pedro S.,
Buss Lewis F.,
Costa Silvia F.,
Cunha Carvalho Flavia M.,
Kawakami Joyce,
Taniwaki Noemi N.,
Paiao Heuder,
Silva Bizário Joao C.,
Jesus Jaqueline G.,
Sabino Ester C.,
Romano Camila M.,
Grepan Regina M. Z.,
Sesso Antonio
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.27021
Subject(s) - virology , replication (statistics) , viral replication , virus , disease , covid-19 , medicine , viral disease , biology , infectious disease (medical specialty) , outbreak
Abstract It has been estimated that individuals with COVID‐19 can shed replication‐competent virus up to a maximum of 20 days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS‐CoV‐2 during the different phases of COVID‐19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication‐competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication‐competent virus for 24 and 37 days, respectively, after symptom onset.