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Molecular characterization of HTLV‐1 genomic region hbz from patients with different clinical conditions
Author(s) -
Cucco Marina Silveira,
Moraes Laise Eduarda Paixão,
Oliveira Andrade Felipe,
Khouri Ricardo,
GalvãoCastro Bernardo,
Araujo Thessika Hialla Almeida,
Almeida Rego Filipe Ferreira,
Gois Luana Leandro,
Barreto Fernanda Khouri,
Santos Luciane Amorim
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.27005
Subject(s) - tropical spastic paraparesis , human t lymphotropic virus 1 , virology , asymptomatic carrier , mutation , leukemia , myelopathy , biology , virus , asymptomatic , gene , lymphoma , immunology , medicine , genetics , t cell leukemia , pathology , spinal cord , neuroscience
The human T‐cell lymphotropic virus type‐1 (HTLV‐1) is associated with severe pathologies, such as HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T‐cell leukemia‐lymphoma (ATLL), and infective dermatitis associated with the HTLV‐1 (IDH). Interestingly, HTLV‐1 infection does not necessarily imply the development of pathological processes and it is unknown why some patients remain asymptomatic carriers (AC). Despite some mutations in the HTLV‐1 genome appear to influence the outcome of HTLV‐1, there are few studies that characterize molecularly the hbz region. This study aimed to perform the molecular characterization of hbz gene isolated from patients with different clinical outcomes. A total of 15 sequences were generated and analyzed with 571 sequences previously published. The analises showed that the R119Q mutation seems to be related to HTLV‐1 clinical conditions since the frequency of this HBZ mutation is significantly different in comparison between AC with HAM/TSP and ATLL. The R119Q mutation is possibly a protective factor as the frequency is higher in AC sequences.