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Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda
Author(s) -
Tushabe Phionah,
Howard Wayne,
Bwogi Josephine,
Birungi Molly,
Eliku James P.,
Kakooza Proscovia,
Bukenya Henry,
Namuwulya Prossy,
Gaizi Joseph,
Tibanagwa Mayi,
Kabaliisa Theopista,
Mulindwa Julius,
Muhanguzi Dennis,
Suchard Melinda,
Gumede Nicksy,
Bakamutumaho Barnabas
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26804
Subject(s) - acute flaccid paralysis , enterovirus , echovirus , poliomyelitis , coxsackievirus , virology , paralysis , poliovirus , medicine , serotype , phylogenetic tree , enterovirus infections , biology , virus , surgery , gene , genetics
Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non‐polio enteroviruses (NPEVs). Specific NPEVs have been described in polio‐like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV‐B5), CV‐B6, E21, and EV‐B69 were only seen in patients with residual paralysis. Analyses of the EV‐A71 sequence indicated a unique genogroup.