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Investigation of dengue–malaria coinfection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon
Author(s) -
Galani Borris R. T.,
Mapouokam Danielle W.,
Simo Fredy B. N.,
Mohamadou Hassimi,
Chuisseu Pascal D. D.,
Njintang Nicolas Y.,
Moundipa Paul F.
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26732
Subject(s) - coinfection , dengue fever , malaria , medicine , chills , dengue virus , odds ratio , tropical medicine , immunology , virology , human immunodeficiency virus (hiv) , pathology
This study aimed at evaluating the seroprevalence of dengue among malarious patients consulting at the Ngaoundere Regional Hospital. During 2 months and a half, 174 participants were recruited and their blood samples were screened for Plasmodium spp and then for Dengue virus (DENV) infection using rapid diagnostic tests. Also, hematological asparameters were measured using a hematology autoanalyzer. Among patients tested, 134 (77.01%) were malaria‐positive, and 12/134 (8.95%) were coinfected. In this population, 8/12 (66.67%) were only anti‐DENV IgM‐positive, 3/12 (25%) were both NS1 and anti‐DENV IgM positive, and 1/12 (8.33%) were anti‐DENV IgG‐positive. Furthermore, women were more affected (58.3%) than men (41.7%). The most affected age groups were young people aged less than or equal to 15 years (33.3%) and adults aged between 30 and 45 years (33.3%). A significant association ( p  < .05; odds ratio [OR] = 5.16) was found between the age range (30–45) and dengue–malaria coinfection. Similarly, we noted a significant association between the coinfection, and joint pain ( p  < .05; OR = 6.15), fatigue ( p  < .01; OR = 5.74), and chills ( p  < .05; OR = 0 ) . Analysis of hematologic parameters showed a significant decrease ( p  < .001) in platelets in coinfected patients compared with monoinfected patients. In conclusion, dengue–malaria coinfection is a reality in Ngaoundere city and associated with the appearance of clinical features which predict the disease severity.

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