Premium
Passive immunity in newborn from SARS‐CoV‐2‐infected mother
Author(s) -
Cavaliere Anna F.,
Marchi Laura,
Aquilini Donatella,
Brunelli Tamara,
Vasarri Pier L.
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26609
Subject(s) - passive immunity , transplacental , immunity , immunology , virology , medicine , antibody , asymptomatic , offspring , in utero , transmission (telecommunications) , immunoglobulin m , fetus , immunoglobulin g , pregnancy , biology , immune system , placenta , electrical engineering , genetics , engineering
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vertical transmission is an open issue. Recent reports call into question in utero or peripartum viral transmission to the offspring. Few data are available on immunoglobulin G (IgG) and/or IgM in newborns. Insufficient evidence is available regarding passive immunity in neonates born from SARS‐CoV‐2 infected women. We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS‐CoV‐2‐infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity.