Premium
Clinical and radiological diagnosis of non–SARS‐CoV‐2 viruses in the era of COVID‐19 pandemic
Author(s) -
Alpaydin Aylin O.,
Gezer Naciye S.,
Simsek Gokçen O.,
Tertemiz Kemal C.,
Kutsoylu Oya O. E.,
Zeka Arzu N.,
Guzel Irmak,
Soyturk Mujde,
Sayiner Ayca A.,
Oguz Vildan A.
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26410
Subject(s) - medicine , coinfection , pandemic , odds ratio , pneumonia , virology , coronavirus , sputum , covid-19 , human metapneumovirus , confidence interval , respiratory system , tuberculosis , virus , pathology , infectious disease (medical specialty) , disease , respiratory tract infections
Following the announcement of the first coronavirus disease 2019 (COVID‐19) case on 11 March 2020 in Turkey, we aimed to report the coinfection rates, and the clinical, laboratory, radiological distinctive features of viral pneumonia caused by viruses other than severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). A cross‐sectional study was conducted between 18 and 31 March 2020. COVID‐19 suspected cases admitted to pandemic policlinic, who had nasopharyngeal swab specimens tested for both SARS‐CoV‐2 and other respiratory viral pathogens, were included. Among 112 patients, SARS‐CoV‐2 was detected in 34 patients (30%). Among the non–SARS‐CoV‐2 viruses ( n = 25, 22%), metapneumovirus ( n = 10) was the most frequent agent. There were two coinfections with SARS‐CoV‐2. Sputum was less in the SARS‐CoV‐2 group ( P = .003). The leukocyte, lymphocyte, and thrombocyte count and C‐reactive protein levels were the lowest in the SARS‐CoV‐2 group ( P < .001, P = .04, P < .001, P = .007, respectively). Peripheral involvement (80% vs 20%; P ≤ .001), pure ground‐glass opacity (65% vs 33%; P = .04), apicobasal gradient (60% vs 40%; P = .08), involvement of greater than or equal to three lobes (80% vs 40%; odds ratio: 6.0; 95% confidence interval: 1.33‐27.05; P = .02), and consolidation with accompanying ground‐glass opacity (4% vs 33%; P = .031) were more common in SARS‐CoV‐2 group. Some clinical, laboratory, and radiological findings may help in the differential diagnosis of non–SARS‐CoV‐2 viruses from COVID‐19. However, coinfections may occur, and a non–SARS‐CoV‐2 pathogen positivity does not exclude accompanying COVID‐19.