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Risk factors and outcomes of COVID‐19 in New York City; a retrospective cohort study
Author(s) -
Gerwen Maaike,
Alsen Mathilda,
Little Christine,
Barlow Joshua,
Genden Eric,
Naymagon Leonard,
Tremblay Douglas
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26337
Subject(s) - medicine , retrospective cohort study , odds ratio , mechanical ventilation , confidence interval , cohort , cohort study , risk factor
Coronavirus disease 2019 (COVID‐19) is a global pandemic and information on risk factors for worse prognosis is needed to accurately identify patients at risk and potentially provide insight into therapeutic options. In this retrospective cohort study, including 3703 patients with laboratory confirmed COVID‐19, we identified risk factors associated with all‐cause mortality, need for hospitalization and mechanical ventilation. Male gender was independently associated with increased risk of hospitalization (adjusted odds ratio [OR adj ]: 1.62; 95% confidence interval [95% CI]: 1.38‐1.91)), mechanical ventilation (OR adj : 1.35; 95% CI: 1.08‐1.69) and death (OR adj : 1.46; 95% CI: 1.17‐1.82). Patients > 60 years had higher risk of hospitalization (OR adj : 5.47; 95% CI: 4.29‐6.96), mechanical ventilation (OR adj : 3.26; 95% CI: 2.08‐5.11) and death (OR adj : 13.04; 95% CI: 6.25‐27.24). Congestive heart failure (ORadj: 1.47; 95% CI: 1.06‐2.02) and dementia (OR adj : 2.03; 95% CI: 1.46‐2.83) were associated with increased odds of death, as well as the presence of more than two comorbidities (OR adj : 1.90; 95% CI: 1.35‐2.68). Patients with COVID‐19 of older age, male gender, or having more than two comorbidities are at higher risk of hospitalization, mechanical ventilation and death, and should therefore be closely monitored.