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The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV‐infected cells
Author(s) -
Dai Lu,
Jung BockGie,
Chen Jungang,
Samten Buka,
Forrest James Craig,
Post Steven R.,
Qin Zhiqiang
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26291
Subject(s) - primary effusion lymphoma , virology , mycobacterium tuberculosis , tuberculosis , biology , virulence , virus , antigen , immunology , pathogen , microbiology and biotechnology , medicine , gene , biochemistry , pathology
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma, which are mostly seen in immunocompromised patients, such as human immunodefeciency virus (HIV)+ individuals. Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis ( Mtb ), remains one of the deadliest infectious diseases in the world. The risk of developing TB is dramatically higher in people living with HIV than among those without HIV infection. Case reports link cutaneous or pulmonary KS in HIV+ patients with mycobacterial co‐infections, however, impacts of Mtb infection or its products on KSHV‐infected cells are not known. We report here that ESAT‐6, a secreted Mtb virulence factor, induces viral reactivation from KSHV‐infected cells. KSHV‐infected pulmonary endothelial cells were resistant to ESAT‐6 induced inhibition of cell growth. Our data demonstrate that Mtb virulence factors influence the biology of KSHV‐infected cells, highlighting the need to study the interactions between these two pathogens commonly found in people living with HIV.