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Clinical exacerbation of SARS‐CoV2 infection after fingolimod withdrawal
Author(s) -
GomezMayordomo Victor,
MonteroEscribano Paloma,
MatíasGuiu Jordi A.,
GonzálezGarcía Nuria,
PortaEtessam Jesús,
MatíasGuiu Jorge
Publication year - 2021
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26279
Subject(s) - virology , fingolimod , covid-19 , medicine , exacerbation , immunology , infectious disease (medical specialty) , multiple sclerosis , outbreak , disease
The role of disease‐modifying therapies in patients with autoimmune disorders during severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) infection is controversial. Immunocompromised patients could have a more severe coronavirus disease‐2019 (COVID‐19) due to the absence of an adequate immune response against the SARS‐CoV‐2. However, therapies that act on immune response could play a protective role by dampening the cytokine‐release syndrome. Fingolimod is a drug used for immune therapy in patients with multiple sclerosis (MS) through the sequestration of activated lymphocytes in the lymph nodes. We report the case of a 57‐year‐old man with relapsing‐remitting MS treated with fingolimod that showed a reactivation of COVID‐19 with signs of hyperinflammation syndrome after fingolimod withdrawal. Our case suggests that discontinuation of fingolimod during COVID‐19 could imply a worsening of SARS‐CoV2 infection.