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The long‐standing history of Corynebacterium parvum , immunity, and viruses
Author(s) -
Palmieri Beniamino,
Vadalà Maria,
Roncati Luca,
Garelli Andrea,
Scandone Francesco,
Bondi Moreno,
Cermelli Claudio
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26100
Subject(s) - virology , immunity , biology , microbiology and biotechnology , virus , corynebacterium parvum , immune system , immunology
We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes) . This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD‐19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.