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Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam
Author(s) -
Phan Lan T.,
Nguyen Thuong V.,
Huynh Loan K. T.,
Dao Manh H.,
Vo Tho A. N.,
Vu Nhung H. P.,
Pham Hang T. T.,
Nguyen Hieu T.,
Nguyen Thuc T.,
Le Hung Q.,
Nguyen Thinh V.,
Nguyen Quan H.,
Huynh Thao P.,
Nguyen Sang N.,
Nguyen Anh H.,
Nguyen Ngoc T.,
Nguyen Thao N. T.,
Nguyen Long T.,
Luong Quang C.,
Cao Thang M.,
Pham Quang D.
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26075
Subject(s) - virology , covid-19 , coronavirus , sequence (biology) , genome , betacoronavirus , isolation (microbiology) , respiratory system , medicine , patient isolation , whole genome sequencing , severe acute respiratory syndrome coronavirus , biology , gene , genetics , bioinformatics , pathology , outbreak , disease , infectious disease (medical specialty)
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS‐CoV‐2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human‐to‐human transmission of SARS‐CoV‐2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi‐morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.