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Effects of methylprednisolone use on viral genomic nucleic acid negative conversion and CT imaging lesion absorption in COVID‐19 patients under 50 years old
Author(s) -
Gong Yuan,
Guan Li,
Jin Zhu,
Chen Shixiong,
Xiang Guangming,
Gao Baoan
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.26052
Subject(s) - covid-19 , virology , lesion , methylprednisolone , nucleic acid , absorption (acoustics) , virus , medicine , biology , pathology , physics , optics , genetics , outbreak , disease , infectious disease (medical specialty)
The use of corticosteroids has been controversial in viral pneumonia. In most cases, application of methylprednisolone in severe and critical viral pneumonia patients can quickly alleviate the symptoms of dyspnea and prevent disease progression. However, some scholars have confirmed that corticosteroids delayed the body's clearance of the virus. In our retrospective non‐randomized study, 34 patients under 50 years old and diagnosed with coronavirus disease 2019 (COVID‐19) were included. According to the given methylprednisolone treatment (n = 18) or not (n = 16), they were separated into two groups. By comparing the clinical data we concluded that corticosteroids therapy can effectively release COVID‐19 symptoms such as persistent fever and difficult in breathing, improve oxygenation, and prevent disease progression. However, it can prolong the negative conversion of nucleic acids.