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TUDCA inhibits HSV‐1 replication by the modulating unfolded protein response pathway
Author(s) -
Su Airong,
Wang Huanru,
Zheng Datong,
Wu Zhiwei
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25963
Subject(s) - tauroursodeoxycholic acid , unfolded protein response , endoplasmic reticulum , viral replication , protein kinase r , herpes simplex virus , kinase , microbiology and biotechnology , biology , virology , eif 2 kinase , protein kinase a , virus , cyclin dependent kinase 2
Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, was used to protect liver function through antiapoptosis or reducing endoplasmic reticulum stress (ER stress). Previous studies showed that ER stress was modulated by herpes simplex virus types 1 (HSV‐1) infection to facilitate viral replication. Here, we investigated the effect of TUDCA on HSV‐1 infection of HEC‐1‐A cells and showed that both replication and multiplication of the virus were inhibited by TUDCA in a dose dependent manner. Unfolded protein response was induced to deliver stress signals from ER to nucleus. We found that TUDCA alleviated activating transcription factor 6 branch inhibition, partially enhanced protein kinase RNA‐like ER kinase pathway activation, and repressed inositol‐requiring protein 1α arm activation significantly in infected cells. The findings of this study suggest that TUDCA inhibits HSV‐1 replication through ER stress pathway, which may provide a potential therapeutic strategy for HSV‐1 infection.