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Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test
Author(s) -
Xie Jiajia,
Ding Chengchao,
Li Jing,
Wang Yulan,
Guo Hui,
Lu Zhaohui,
Wang Jinquan,
Zheng Changcheng,
Jin Tengchuan,
Gao Yong,
He Hongliang
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25930
Subject(s) - nucleic acid test , virology , covid-19 , antibody , medicine , coronavirus , immunoglobulin m , immunology , nucleic acid , virus , immunoglobulin g , pandemic , disease , biology , infectious disease (medical specialty) , biochemistry
Coronavirus disease (COVID‐19), caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly developed into a pandemic since it was first reported in December 2019. Nucleic acid testing is the standard method for the diagnosis of viral infections. However, this method reportedly has a low positivity rate. To increase the sensitivity of COVID‐19 diagnoses, we developed an IgM‐IgG combined assay and tested it in patients with suspected SARS‐CoV‐2 infection. In total, 56 patients were enrolled in this study and SARS‐CoV‐2 was detected by using both IgM‐IgG antibody and nucleic acid tests. Clinical and laboratory data were collected and analyzed. Our findings suggest that patients who develop severe illness might experience longer virus exposure times and develop a more severe inflammatory response. The IgM‐IgG test is an accurate and sensitive diagnostic method. A combination of nucleic acid and IgM‐IgG testing is a more sensitive and accurate approach for diagnosis and early treatment of COVID‐19.