Premium
Epidemiology and persistence of cervical human papillomavirus infection among outpatient women in Heilongjiang province: A retrospective cohort study
Author(s) -
Liu Jiaxin,
Shi Yafeng,
Wang Lishuang,
Wang Jiao,
Fan Dongxue,
Han Shiyu,
Wei Lanlan
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25899
Subject(s) - medicine , hpv infection , genotyping , persistence (discontinuity) , epidemiology , retrospective cohort study , cervical cancer , logistic regression , cohort , human papillomavirus , cervical intraepithelial neoplasia , population , gynecology , virology , genotype , cancer , biology , genetics , gene , environmental health , geotechnical engineering , engineering
As persistent carcinogenic human papillomavirus (HPV) infection is a prominent driver of cervical cancer, it is essential to explore HPV persistence and its associated factors for cancer screening and prevention. A retrospective cohort study was performed in outpatient women between March 2010 and 2019 in Heilongjiang, northeast China. HPV genotyping was performed by polymerase chain reaction‐membrane hybridization. An unconditional logistic regression model was used to analyze the association of factors with persistence. The overall prevalence of HPV at baseline was 27.1%, with a downward trend from 2010 to 2019 ( P < .0001). The most commonly observed high‐ and low‐risk HPVs were HPV16 (N = 1094, 5.9%) and HPV11 (N = 596, 3.2%), respectively. The probabilities of 6‐month persistence were high for women infected with HPV16 ( P = .0001), HPV58 ( P = .018), and HPV53 ( P = .014), as well as for women with multiple infections ( P = .009), and those who were 51 to 60 years old ( P = .004) or more than 60 years old ( P = .007). The probabilities of 12‐month persistence were high for women infected with HPV53 ( P = .017) and 51‐ to 60‐year‐old women ( P = .044). HPV16 is the dominant HPV type in Heilongjiang. An age in the range of 51 to 60 years and infection with HPV53 is associated with HPV infection persistence in the Heilongjiang population.