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Comparison of medication adherence and satisfaction between entecavir and tenofovir alafenamide therapy in chronic hepatitis B
Author(s) -
Tamaki Nobuharu,
Kurosaki Masayuki,
Nakanishi Hiroyuki,
Itakura Jun,
Inada Kento,
Kirino Sakura,
Yamashita Koji,
Osawa Leona,
Sekiguchi Shuhei,
Hayakawa Yuka,
Wang Wan,
Okada Mao,
Higuchi Mayu,
Takaura Kenta,
Maeyashiki Chiaki,
Kaneko Shun,
Yasui Yutaka,
Tsuchiya Kaoru,
Takahashi Yuka,
Izumi Namiki
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25692
Subject(s) - entecavir , tenofovir alafenamide , medicine , chronic hepatitis , forgetting , virology , human immunodeficiency virus (hiv) , psychology , viral load , antiretroviral therapy , virus , cognitive psychology , lamivudine
Adherence to nucleotide/nucleoside analog therapy is important in improving prognosis in chronic hepatitis B. We aimed to compare medical adherence and satisfaction with entecavir (ETV) and tenofovir alafenamide (TAF) and to assess the effect of switching from ETV to TAF. Patients taking ETV (n = 114) and TAF (n = 35), and who switched from ETV to TAF (n = 15) were included. Medication adherence and satisfaction were assessed using a questionnaire. There was no significant difference in adherence between the ETV and TAF groups, but the medication satisfaction rates (0‐10, prefer‐dislike) were 1.72 ± 2.2 and 0.69 ± 1.5, respectively ( P = .01; significantly higher in the TAF group). In patients who switched from ETV to TAF, medication adherence significantly improved ( P = .04) as follows: never forgetting, from 40% to 87%; forgetting once every 2 to 3 months, from 33% to 7%; forgetting once every 2 months, from 20% to 7%, and forgetting once every 4 weeks, from 7% to 0%. Similarly, the medication satisfaction rate significantly improved from 4.53 ± 3.2 to 1.27 ± 2.4 after switching ( P = .008). In conclusion, switching from ETV to TAF can be a useful approach to improve medication adherence and satisfaction.