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The 2019‐new coronavirus epidemic: Evidence for virus evolution
Author(s) -
Benvenuto Domenico,
Giovanetti Marta,
Ciccozzi Alessandra,
Spoto Silvia,
Angeletti Silvia,
Ciccozzi Massimo
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25688
Subject(s) - phylogenetic tree , coronavirus , biology , virology , genome , phylogenetics , betacoronavirus , virus , genetics , sequence analysis , molecular epidemiology , pandemic , middle east respiratory syndrome , middle east respiratory syndrome coronavirus , glycoprotein , mutation , homology (biology) , gene , covid-19 , infectious disease (medical specialty) , genotype , medicine , disease , pathology
There is a worldwide concern about the new coronavirus 2019‐nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019‐nCoV, 12 whole genome sequences of 2019‐nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS‐like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019‐nCoV significantly clustered with bat SARS‐like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019‐nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.