Premium
Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness
Author(s) -
Maleki Faezeh,
Sadigh ZohrehAzita,
Sadeghi Farzin,
Muhammadnejad Ahad,
Farahmand Mohammad,
Parvin Mahmoud,
Shirkoohi Reza
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25673
Subject(s) - human cytomegalovirus , glioma , cytomegalovirus , immunohistochemistry , virus , polymerase chain reaction , taqman , virology , medicine , gene , immunology , biology , herpesviridae , viral disease , cancer research , biochemistry
Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is a matter for consideration in broad‐spectrum diseases, specifically in immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high‐grade gliomas, have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through TaqMan real‐time polymerase chain reaction and immunohistochemistry, respectively. The results were positive for the UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency of HCMV was significantly higher in glioblastomas than other glioma grades ( P < .01 and P < .05 for the UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its role in glial tumors, its prognostic value, and possible efficient antiviral target therapy.