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Association of polymorphisms in the vitamin D receptor gene with susceptibility to and severity of hand, foot, and mouth disease caused by coxsackievirus A16
Author(s) -
Li YaPing,
Wang MuQi,
Deng HuiLing,
Li Mei,
Zhang Xin,
Dang ShuangSuo,
Zhai Song
Publication year - 2020
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25603
Subject(s) - calcitriol receptor , single nucleotide polymorphism , genotype , odds ratio , linkage disequilibrium , medicine , foot and mouth disease , gastroenterology , biology , coxsackievirus , vitamin d and neurology , immunology , genetics , gene , virus , enterovirus
Coxsackievirus A16 (CA16) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and is related to high incidence and critical complications. Vitamin D receptor (VDR) activity might affect the outcome of CA16 infection. Our case‐control research aims to evaluate the relationship between VDR polymorphisms in the gene encoding and susceptibility to and severity of HFMD due to CA16. Three single‐nucleotide polymorphisms (SNPs) of VDR gene were selected according to functional prediction and linkage disequilibrium, and were examined utilizing the SNPscan method to identify possible associations with HFMD caused by CA16. A significant relationship was found in the HFMD cases of polymorphism rs11574129 (GA vs GG: odds ratio (OR) = 0.068, 95% confidence interval (CI) = 0.007‐0.693, P = .023; GA + AA vs GG: OR = 0.322, 95%CI = 0.106‐0.984, P = .047), and vitamin D levels in genotype AA were significantly higher than those in genotype GG ( P < .05). These results suggest that VDR rs11574129 may influence genetic susceptibility to CA16‐associated HFMD.