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Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil
Author(s) -
Castro Luanda R. P.,
Calvet Flávio C.,
Sousa Karoline L.,
Silva Victor P.,
Lobo Patrícia S.,
Penha Edvaldo T.,
Guerra Sylvia F. S.,
Bezerra Delana A. M.,
Mascarenhas Joana D. P.,
Pinheiro Helder H. C.,
Costa Igor B.,
Resque Hugo R.,
Soares Luana S.
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25569
Subject(s) - human bocavirus , transplantation , rotavirus , diarrhea , population , epidemiology , kidney transplantation , genotype , virology , feces , medicine , outbreak , biology , immunology , environmental health , microbiology and biotechnology , respiratory tract infections , respiratory system , biochemistry , gene
Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients. This study aimed to describe the occurrence of Rotavirus A (RVA) and Human Bocavirus (HBoV) in fecal samples of immunosuppressed patients submitted to renal transplantation during posttransplant follow‐up. A longitudinal study was carried out involving a 25‐patient cohort, selected for kidney transplantation. A total of 126 fecal samples were collected between May 2014 and May 2016. Molecular techniques were used to detect and characterize circulating RVA and HBoV genotypes and statistical analysis were applied to verify the association between epidemiological and clinical characteristics. The prevalence of RVA and HBoV was 24% (6/25) and 40% (10/25), respectively. Among RVA and HBoV positive cases, the majority was female; did not conduct water treatment nor had adequate sewage facilities. The most detected genotypes were RVA G3 (62.5%) and HBoV‐3 (95%). Phylogenetic analysis of HBoV strains indicated that studied samples were similar to those found in Asian and American countries. The present study point out the circulation of these viral agents among immunosuppressed individuals and these findings will enable the construction of new knowledge and care perspectives on the cause of diarrhea in this population.