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Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro
Author(s) -
Gong Meijiao,
Li Shifang,
Xie Yinli,
Zhao Furong,
Shao Junjun,
Zhang Yongguang,
Wang Wenhui,
Chang Huiyun
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25494
Subject(s) - homoharringtonine , virology , virus , medicine , foot and mouth disease virus , in vitro , in vivo , disease , pharmacology , biology , immunology , microbiology and biotechnology , myeloid leukemia , biochemistry
Foot‐and‐mouth disease (FMD) is a highly contagious disease that affects cloven‐hoof animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS‐2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time‐of‐addition assays, we found that the antiviral activity of homoharringtonine occurred primarily during the early stage of infection. These results demonstrated that homoharringtonine might be an effective anti‐FMDV drug. Further studies are required to explore the antiviral activity of homoharringtonine against FMDV replication in vivo.