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Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy
Author(s) -
Anselmo Alessandro,
Prezioso Carla,
Saccà Filippo Antonino,
Di Lella Federica Maria,
Palmieri Giampiero,
Tisone Giuseppe,
Pietropaolo Valeria,
Ciotti Marco
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25458
Subject(s) - virology , point mutation , mutation , viral replication , kidney , kidney transplantation , nephropathy , medicine , replication (statistics) , kidney transplant , risk factor , biology , virus , genetics , gene , diabetes mellitus , endocrinology
BKPyV replication is a risk factor for the development of polyomavirus‐associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor‐1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b‐1.