LAP +  Treg is a better biomarker than total Treg in viral myocarditis | Zendy

Wang Xinggang | Zendy; Ge Junbo | Zendy; Chen Ruizhen | Zendy

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LAP + Treg is a better biomarker than total Treg in viral myocarditis

Author(s) -

Wang Xinggang,

Ge Junbo,

Chen Ruizhen

Publication year - 2019

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.25378

Subject(s) - treg cell , biomarker , immunology , myocarditis , inflammation , viral myocarditis , virology , medicine , biology , virus , immune system , t cell , il 2 receptor , genetics

Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP + Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP + Treg out of CD4 + cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4 + cells. Comparing with the previously recognized total Treg, LAP + Treg was a better biomarker on myocardial inflammation.

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