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LAP + Treg is a better biomarker than total Treg in viral myocarditis
Author(s) -
Wang Xinggang,
Ge Junbo,
Chen Ruizhen
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25378
Subject(s) - treg cell , biomarker , immunology , myocarditis , inflammation , viral myocarditis , virology , medicine , biology , virus , immune system , t cell , il 2 receptor , genetics
Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP + Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP + Treg out of CD4 + cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4 + cells. Comparing with the previously recognized total Treg, LAP + Treg was a better biomarker on myocardial inflammation.