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Serological evidence of human infection by bat orthoreovirus in Singapore
Author(s) -
Uehara Anna,
Tan Chee Wah,
Mani Shailendra,
Chua Kaw Bing,
Leo Yee Sin,
Anderson Danielle E,
Wang LinFa
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25355
Subject(s) - virology , serology , immunoprecipitation , biology , virus , antibody , viral disease , neutralization , immunology
To determine whether Pteropine orthoreovirus (PRV) exposure has occurred in Singapore, we tested 856 individuals from an existing serum panel collected from 2005‐2013. After an initial screen with luciferase immunoprecipitation system and secondary confirmation with virus neutralization test, we identified at least seven individuals with specific antibodies against PRV in both assays. Our findings confirm that PRV spillover into human populations is relatively common in this region of the world.