Identification of hepatitis B virus genotype I in Thailand | Zendy

Holzmayer Vera | Zendy; Hance Robert | Zendy; Defechereux Patricia | Zendy; Grant Robert | Zendy; Kuhns Mary C. | Zendy; Cloherty Gavin | Zendy; Rodgers Mary A. | Zendy

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Identification of hepatitis B virus genotype I in Thailand

Author(s) -

Holzmayer Vera,

Hance Robert,

Defechereux Patricia,

Grant Robert,

Kuhns Mary C.,

Cloherty Gavin,

Rodgers Mary A.

Publication year - 2019

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.25346

Subject(s) - virology , hepatitis b virus , genotype , biology , hbsag , genome , hepadnaviridae , orthohepadnavirus , virus , recombinant dna , genetics , gene

The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV‐I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV‐I classification as a unique genotype.

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