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A cross‐sectional serum investigation of a clustering hepatitis C virus infection in Southwest China
Author(s) -
Peng Haoran,
Zhang Longyan,
Feng Yue,
Tang Hailin,
Luo Zhenghan,
Qi Zhongtian,
Xia Xueshan,
Zhao Ping
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25315
Subject(s) - hepatitis c virus , virology , antibody , virus , viral load , biology , medicine , immunology
Serum samples were collected in a village with a clustering hepatitis C virus (HCV) infection. HCV antibody, HCV RNA loads, liver function indexes, HCV envelope antibody, and neutralizing activity were assessed. Among 851 adult sera, 342 samples were positive for anti‐HCV. Of these positive samples, 254 (74.3%) were HCV RNA positive (≥800 copies/mL). None of the 69 children's sera were positive for HCV antibody or RNA. Among the HCV antibody positive sera, alanine aminotransferase, and aspartate aminotransferase levels increased with the higher virus loads, but decreased when virus loads were higher than 1 × 10 6 copies/mL. HCV envelope antibody and neutralizing antibody levels increased with viral load.