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Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009‐2015
Author(s) -
Zhang Ming,
Zhao Yilin,
Zhang Haihao,
Lin Keqin,
Liu Hongbo,
Zhang Jie,
Ding Lisha,
Huang Xiaoqin,
Yang Zhaoqing,
Ma Shaohui
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25297
Subject(s) - foot and mouth disease , virology , aseptic meningitis , hand foot and mouth disease , coxsackievirus , medicine , biology , disease , veterinary medicine , meningitis , virus , pediatrics , enterovirus
Coxsackievirus A16 (CV‐A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV‐A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV‐A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 −3 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV‐A16 and develop a CV‐A16 vaccine.