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Detection of rotavirus‐ and norovirus‐specific IgG memory B cells in tonsils
Author(s) -
Sharma Sumit,
Hagbom Marie,
Nordgren Johan,
Frodlund Jonas,
Hinkula Jorma,
Ledin Torbjörn,
Svensson Lennart
Publication year - 2019
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25247
Subject(s) - norovirus , virology , rotavirus , biology , antigen , virus , memory b cell , immune system , antibody , immunology , b cell , microbiology and biotechnology
Because rotavirus (RV) and norovirus (NoV) are transmitted through the fecal‐oral route, tonsils due to their location within the oropharynx may sample or become infected with these viruses. We investigated if RV and NoV RNA/antigen, or virus‐specific memory/plasma B cells can be detected in the tonsils. While neither RV/NoV antigen, nor genomic RNA was detected, 90% (27/30) of tonsils tested had RV‐ and NoV‐specific IgG memory B cells. However, the mechanism explaining how these cells get there (whether because of local induction or homing after induction at other sites) and the role these cells might play during active infection is not yet clear.