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High prevalence and correlates of human herpesvirus‐6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai
Author(s) -
Ding Ling,
Mo Xiaohui,
Zhang Liming,
Zhou Feng,
Zhu Caixia,
Wang Yuyan,
Cai Cankun,
Liu Yeqiang,
Wei Fang,
Cai Qiliang
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25217
Subject(s) - virus , seborrheic dermatitis , dermatology , medicine , immunology , herpesviridae , human herpesvirus 6 , cytomegalovirus , virology , seborrheic keratosis , sarcoma , pathology , viral disease
Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. To reveal the potential link of a certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV‐6A in inflammatory or neoplastic skin tissues is the most common (40.3%), followed by Epstein‐Barr virus (17.6%), Kaposi’s sarcoma‐associated herpesvirus (KSHV; 9.2%), HHV‐6B (4.4%), human cytomegalovirus (1.1%), and varicella‐zoster virus (0.7%); albeit the co‐infection of HHV‐6A, Epstein‐Barr virus, and KSHV presents to a less extent and none of HSV‐1, HSV‐2, or HHV‐7 were detected. Moreover, HHV‐6A infection is highly associated with nevocytic nevus and seborrheic dermatitis/keratosis diseases, which mainly occur in the head and the neck or the lower limb. Despite no significant difference among the HHV infections in different age groups of skin patient tissues, the distribution of KSHV infection was exclusively and significantly higher (~3.7‐fold) in male skin patients.