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Hepatitis A vaccine immune response 22 years after vaccination
Author(s) -
Mosites Emily,
Gounder Prabhu,
Snowball Mary,
Morris Julie,
Spradling Philip,
Nelson Noele,
Bulkow Lisa,
Bruce Michael,
McMahon Brian
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25197
Subject(s) - hepatitis a vaccine , immunogenicity , medicine , vaccination , virology , hepatitis a , booster dose , incidence (geometry) , booster (rocketry) , immunology , cohort , immune system , hepatitis , pediatrics , immunization , physics , astronomy , optics
In the United States, the incidence of hepatitis A virus (HAV) infection has been reduced through universal childhood vaccination. However, the duration of immunogenicity for the hepatitis A vaccine is not known. We report on the 22 year follow‐up time point of a cohort of Alaska children who were randomized to three different vaccine schedules: A) 0, 1, and 2 months; B) 0, 1, and 6 months; and C) 0, 1, and 12 months. Among 46 participant available for follow‐up, 40 (87%) maintained protective levels of anti‐hepatitis A antibody. These results indicate that a supplemental booster dose is not yet necessary at or before the 22‐year time point.