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Mutations within the major hydrophilic region (MHR) of Hepatitis B virus from individuals with simultaneous HBsAg and anti‐HBs in Guangzhou, Southern China
Author(s) -
Liu Kemin,
Xie Mingyu,
Lu Xiaomei,
Yu Hui,
Wang Hui,
Xu Yunjian,
Yang Qingqing,
Lin Yongping,
Ma Qiang
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25188
Subject(s) - hbsag , hepatitis b virus , virology , hepatitis b , chronic hepatitis , medicine , group a , virus , carriage , gastroenterology , pathology
The mechanism of the coexistence of HBsAg and anti‐HBs is still unclear. This study investigated the variations located in the major hydrophilic region (MHR) of HBV from individuals with simultaneous HBsAg and anti‐HBs in Guangzhou, southern China. Among 4455 samples analyzed, 179 (4.02%) patients were discovered with both HBsAg and anti‐HBs. Finally, 44 individuals with concurrent HBsAg and anti‐HBs (defined as group I), and 88 patients with positive HBsAg and negative anti‐HBs (defined as group II, served as control) were enrolled in the study. The number of residue changes per 100 residues within the MHR in group I was 7.1 times more frequent than group II ( P < 0.001) and was discovered mostly in the MHR1 (aa99‐119) ( P < 0.001). Two or more residue changes in the MHR were discovered in 15 patients (34.1%) of group I, but were found in only one (1.1%) patient of group II ( P < 0.001). The most common variants in group I were at positions s101Q, s133M, s126T/I, s131T, s145G, s120P, and s129Q. In addition, sQ101 K, sT131N, and sM133L were more frequently discovered in group I with significant difference ( P < 0.05). In chronic hepatitis B (CHB) patients, the simultaneous of HBsAg and anti‐HBs were accompanied with an increase of MHR variants, and suggested that the HBsAg mutants were selected by naturally acquired anti‐HBs during chronic carriage.