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Comparison between patients with norovirus‐related gastroenteritis and asymptomatic carriers with respect to distribution of antibody‐complexed viral particles and intestinal flora
Author(s) -
Mori Kohji,
Konishi Noriko,
Suzuki Yasunori,
Harada Sachiko,
Maeda Masako,
Akase Satoru,
Obata Hiromi,
Monma Chie,
Nagano Miyuki,
Kimoto Kana,
Oda Mayuko,
Somura Yoshiko,
Hirai Akihiko,
Shinkai Takayuki,
Noda Mamoru,
Sadamasu Kenji
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25079
Subject(s) - norovirus , asymptomatic carrier , asymptomatic , virology , microbiology and biotechnology , outbreak , antibody , diarrhea , biology , medicine , immunology , gastroenterology
Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus‐related community gastroenteritis outbreaks. No significant difference between the two groups was observed in terms of the number of norovirus‐antibody complexes with respect to total numbers. Principal coordinates analysis of the intestinal flora based on β‐diversity analysis, revealed a different bacterial composition between patients and asymptomatic carriers, particularly regarding the genera Pseudomonas , Bacteroides , and Erwinia , as well as the Ruminococcaceae family. Although the proportional changes between these intestinal microorganisms were not sufficient to explain gastroenteritis symptoms, they represent possible markers shared by asymptomatic norovirus carriers.