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Full genomic analysis of G1P[8] rotavirus strains recovered from rotavirus vaccinated and non‐vaccinated children hospitalized for acute gastroenteritis in Pune, western India
Author(s) -
Pradhan Gauri N.,
Chitambar Shobha D.
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25007
Subject(s) - rotavirus , virology , rotavirus vaccine , biology , genotype , genome , acute gastroenteritis , gene , strain (injury) , vaccination , virus , genetics , anatomy
G1P[8] rotaviruses are predominant in causing diarrheal infections in humans all over the world. This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from Rotarix™ vaccine recipients and non‐recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains showed a genogroup‐1 backbone with intra‐genotypic diversity in the VP7 and VP4 gene segments and a homogeneous constellation of the internal gene segments. A divergence in the range of 1.4‐17.3% from Rotarix™ vaccine strain was revealed by structural and non‐structural genes of the strains at nucleotide and amino acid level. These data reflect ability of such G1P[8] strains to cause rotavirus infections in humans.