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Mixed viral infections of the respiratory tract; an epidemiological study during consecutive winter seasons
Author(s) -
Antalis Emmanouil,
Oikonomopoulou Zacharoula,
Kottaridi Christine,
Kossyvakis Athanasios,
Spathis Aris,
Magkana Maria,
Katsouli Aikaterini,
Tsagris Vassileios,
Papaevangelou Vassiliki,
Mentis Andreas,
Tsiodras Sotirios
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.25006
Subject(s) - epidemiology , respiratory tract infections , medicine , respiratory system , logistic regression , respiratory tract , lower respiratory tract infection , virus , influenza a virus , viral load , virology , immunology
The current study aimed to describe the molecular epidemiology of mixed respiratory viral infections during consecutive winter seasons in a tertiary care hospital. Patients with symptoms of respiratory tract infection were evaluated during the 2009‐2011 and 2013‐15 winter seasons. A clinical microarray technique was used for viral detection. Clinical and epidemiological data were correlated with mixed viral detection and the need for hospitalization. In 332 out of 604 (54.4%) evaluated patients (17.6% children) a respiratory virus was identified. Mixed viral infections were diagnosed in 68/332 (20.5%) patients with virus detection (66.2% mixed Influenza‐RSV infections). Mixed viral infections were more commonly detected in children (OR 3.7; 95%CI 1.9‐5.6, P < 0.01) and patients with comorbidities. In logistic regression analyses, mixed viral infections were associated with younger age (mean age 30.4 years vs. 41.8 years, P ≤ 0.001) and increased rates of fever (OR: 2.7; 95%CI 1.04‐7.2, P < 0.05) but no adverse outcomes or increased rates of hospitalization. High rates of mixed viral infections were noted during all winter seasons (especially Influenza and RSV ) and were more common in younger patients. The clinical significance of mixed respiratory viral infection needs further elucidation.