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Genotypes of human metapneumovirus circulating during 2010‐2012 in children from Panama
Author(s) -
Ábrego Leyda E.,
Mirazo Santiago,
Delfraro Adriana,
Franco Danilo,
Castillo Marlene,
Gaitán Melissa,
Castillo Juan,
Moreno Brechla,
Pascale Juan M.,
Arbiza Juan
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24969
Subject(s) - human metapneumovirus , metapneumovirus , virology , genotype , panama , respiratory tract infections , biology , respiratory system , respiratory tract , medicine , gene , genetics , ecology , anatomy
Human metapneumovirus (HMPV) is a common causative agent of severe respiratory tract infections in children under 5 years old, the elderly and immunocompromised patients, being responsible for 5‐15% of all viral respiratory infections requiring hospitalization. Though HMPV was included in the surveillance program for respiratory viruses in 2010, its genotype distribution remains unknown. Herein, 45 positive samples to HMPV from children ≤5 years old were characterized by phylogenetic analysis based on N gene sequence. Results showed the co‐circulation of four sub‐lineages: A2a (8.8%), A2b (55.5%), B1 (15.6%), and B2 (20%), demonstrating the genetic heterogeneity of HMPV circulating in Panamá.