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Genetic characterization of enterovirus A71 isolates from severe neurological cases in Poland
Author(s) -
Wieczorek Magdalena,
Purzyńska Mariola,
Krzysztoszek Arleta,
Ciąćka Agnieszka,
Figas Agnieszka,
Szenborn Leszek
Publication year - 2018
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24958
Subject(s) - aseptic meningitis , virology , acute flaccid paralysis , outbreak , enterovirus , myelitis , encephalitis , paralysis , meningitis , medicine , virus , biology , pediatrics , poliovirus , surgery , psychiatry , spinal cord
The aim of this study was to report a minor outbreak of enterovirus A71 (EV‐A71) infection in Poland and characterize isolates from cases of severe neurological infection detected in 2013 and 2016. Phylogenetic analysis revealed that Polish strains belonged to the C genogroup: C1, C2, and C4. Severe neurological manifestations as encephalitis or acute flaccid paralysis (AFP), were associated with all detected subgenogroups. The C2 subgenogroup was associated with the outbreak in Gdansk, with serious cases of AFP, myelitis, cerebellitis, encephalitis, but also with mild, sporadic cases of aseptic meningitis, in other Polish cities. Data from the study established relationships of EV‐A71 from Poland with previously characterized strains and confirmed the importance of high quality enterovirus surveillance with international reach.