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No detection of Merkel cell polyomavirus in oral lichen planus: Results of a preliminary study in a French cohort of patients
Author(s) -
Masson Regnault Marie,
Vigarios Emmanuelle,
Projetti Fabrice,
HerbaultBarres Beatrice,
Tournier Emilie,
Lamant Laurence,
Sibaud Vincent
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24887
Subject(s) - merkel cell polyomavirus , oral lichen planus , polyomavirus infections , merkel cell carcinoma , virus , virology , immunology , pathogenesis , cd8 , medicine , merkel cell , dermatology , biology , pathology , antigen , bk virus , carcinoma , transplantation , kidney transplantation
Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte‐mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients with different forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Our preliminary results do not support the hypothesis that OLP may be triggered by MCPyV infection. Further studies are needed to evaluate the involvement of other human polyomaviruses in OLP pathogenesis.