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High prevalence of hepatitis E virus infection in goats
Author(s) -
Long Feiyan,
Yu Wenhai,
Yang Chenchen,
Wang Jue,
Li Yunlong,
Li Yi,
Huang Fen
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24843
Subject(s) - hepatitis e virus , virology , biology , genotype , zoonosis , transmission (telecommunications) , feces , virus , veterinary medicine , hepatitis e , phylogenetic tree , medicine , microbiology and biotechnology , gene , biochemistry , electrical engineering , engineering
Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide, primarily transmitted by fecal‐oral route. Zoonotic transmission of HEV from HEV‐infected pigs (pork) or cows (milk) to human or non‐human primate has been confirmed, but the risk of HEV in goat is still rarely assessed. In the present study, stool, blood, tissues, and milk of goat were collected for HEV infection investigation from Dali City of Yunnan Province in China, where raw mutton and goat milk are traditionally consumed. Surprisingly, a high prevalence of HEV infection in goat was found. Phylogenetic analysis revealed that all HEV isolates from goat belong to genotype 4 and subtype 4h, and shared a high similarity homology (>99.6%) with HEV isolated from human, swine, and cows in the same area. Results suggested that goats are a previously unrecognized HEV host.