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Genetic variability of human respiratory syncytial virus group B in Panama reveals a novel genotype BA14
Author(s) -
Ábrego Leyda E.,
Delfraro Adriana,
Franco Danilo,
Castillo Juan,
Castillo Marlene,
Moreno Brechla,
LópezVergès Sandra,
Pascale Juan M.,
Arbiza Juan
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24838
Subject(s) - panama , genotype , clade , biology , virus , virology , monophyly , genetic variability , genetic variation , paramyxoviridae , genetics , respiratory system , mononegavirales , pneumovirus , phylogenetics , gene , viral disease , ecology , anatomy
In Panama, human respiratory syncytial virus (HRSV) is responsible of 20‐40% of acute respiratory infections in children under 5 years old. Currently, little is known about the genetic variability of HRSV in Central America and the Caribbean. Recently, we reported the genetic variability of HRSV‐A, however; no studies on HRSV‐B in Panama have been described yet. In this study, 24 sequences of Panamanian HRSV‐B, from children (<5 years) with acute respiratory infections (ARI), collected from July 2008 to November 2012 were analyzed. All sequences share the characteristic 60‐nt duplication of the BA strains. Six Panamanian strains grouped with the BA10 genotype and 12 samples clustered together in a separate monophyletic clade with an aLRT support value of 0.92 and an intra‐group p‐distance less than 0.07. This fulfills the criteria to consider a new genotype in HRSV, which we named BA14 genotype. Another six strains remain unclassified, but closely related to BA9, BA11, or the new BA14 genotypes, according to their genetic p‐distance. Different amino acid substitutions in the Panamanian HRSV‐B strains were observed, some previously described and others found only on Panamanian strains. This study contributes to the knowledge of the genetic variability and evolution of HRSV in Central America.