Premium
Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?
Author(s) -
Eijsvoogel Noortje B.,
Hollegien Mirjam I.,
Bok Vinus L. A.,
Derksen−Lubsen Arda G.,
Dikken Felix P. J.,
Leenders Sander A. C. A. P.,
Pijning Arjan.,
Post Erica,
Wojciechowski Marek,
Hilbink Mirrian,
de Vries Esther
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24813
Subject(s) - booster (rocketry) , titer , vaccination , medicine , virology , hepatitis b , booster dose , antibody , immunology , hepatitis b virus , pediatrics , virus , physics , astronomy
We determined the anti‐HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1‐61.3) of the DS children aged 7‐10 years and 31.9% (95%CI: 22.1‐43.6) of the DS children aged >10 years had a protective anti‐HBs titer (≥10 IU/L). The geometric mean anti‐HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.