Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination? | Zendy

Eijsvoogel Noortje B. | Zendy; Hollegien Mirjam I. | Zendy; Bok Vinus L. A. | Zendy; Derksen−Lubsen Arda G. | Zendy; Dikken Felix P. J. | Zendy; Leenders Sander A. C. A. P. | Zendy; Pijning Arjan. | Zendy; Post Erica | Zendy; Wojciechowski Marek | Zendy; Hilbink Mirrian | Zendy; de Vries Esther | Zendy

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Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

Author(s) -

Eijsvoogel Noortje B.,

Hollegien Mirjam I.,

Bok Vinus L. A.,

Derksen−Lubsen Arda G.,

Dikken Felix P. J.,

Leenders Sander A. C. A. P.,

Pijning Arjan.,

Post Erica,

Wojciechowski Marek,

Hilbink Mirrian,

de Vries Esther

Publication year - 2017

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.24813

Subject(s) - booster (rocketry) , titer , vaccination , medicine , virology , hepatitis b , booster dose , antibody , immunology , hepatitis b virus , pediatrics , virus , physics , astronomy

We determined the anti‐HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1‐61.3) of the DS children aged 7‐10 years and 31.9% (95%CI: 22.1‐43.6) of the DS children aged >10 years had a protective anti‐HBs titer (≥10 IU/L). The geometric mean anti‐HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.

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