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Multiple sclerosis‐associated retrovirus, Epstein‐Barr virus, and vitamin D status in patients with relapsing remitting multiple sclerosis
Author(s) -
Mostafa Aliehossadat,
Jalilvand Somayeh,
Shoja Zabihollah,
Nejati Ahmad,
Shahmahmoodi Shohreh,
Sahraian Mohammad Ali,
Marashi Sayed Mahdi
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24774
Subject(s) - multiple sclerosis , retrovirus , virology , peripheral blood mononuclear cell , immunology , antibody , endogenous retrovirus , virus , biology , real time polymerase chain reaction , medicine , gene , genetics , genome , in vitro
The relationship between infections and autoimmune diseases is complex and there are several reports highlighting the role of human endogenous retroviruses (HERVs) in these patients. The levels of multiple sclerosis‐associated retrovirus (MSRV)‐type DNA of Env gene was measured in peripheral blood mononuclear cells from 52 patients with relapsing‐remitting multiple sclerosis (RRMS) and 40 healthy controls using specific quantitative PCR (qPCR) analysis. Furthermore, we analyzed the status of HERV‐W/MSRV in these patients with regards to both EBV (DNA load and anti‐EBNA1 IgG antibody) and vitamin D concentration. MSRV DNA copy number were significantly higher in RRMS patients than healthy controls ( P < 0.0001). Interestingly, an inverse correlation was found between MSRV DNA copy number and serum vitamin D concentration ( P < 0.01), but not for EBV load or anti‐EBNA‐1 IgG antibody.