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HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012
Author(s) -
Wang Binghui,
Liang Yuebo,
Wang Yajuan,
Feng Yue,
Li Yaping,
Zhang Li,
Xuan Qicai,
Miao Jing,
Qin Weihong,
Xia Xueshan
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24740
Subject(s) - phylogenetic tree , human immunodeficiency virus (hiv) , virology , genotype , china , population , southern china , demography , phylogenetics , biology , geography , medicine , gene , environmental health , genetics , archaeology , sociology
Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos, and Myanmar. There are more than 2 million cross‐border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV‐1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91 432 entry travelers were detected to be HIV‐1‐positive, accounting for infection rate of 0.21%. Eighty‐one gag‐pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV‐1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B’ (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV‐1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV‐1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies.