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MicroRNA‐649 promotes HSV‐1 replication by directly targeting MALT1
Author(s) -
Zhang Yi,
Dai Jun,
Tang Jinfeng,
Zhou Li,
Zhou Mengzhou
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24728
Subject(s) - biology , virology , herpes simplex virus , viral replication , microrna , virus , hsl and hsv , neurotropic virus , cancer research , gene , genetics
Herpes simplex virus type 1 (HSV‐1), a member of the Herpesviridae, is associated with a wide variety of nervous system diseases including meningitis and encephalitis. The data presented here demonstrate that miR‐649 promotes the replication of HSV‐1 without affecting cell viability. Further mechanistic studies revealed that MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1) is directly targeted by miR‐649. We then found that MALT1 and the downstream NF‐κB signaling pathway, are involved in miR‐649‐induced HSV‐1 replication. Interestingly, miR‐649 levels were downregulated after HSV‐1 infection, and miR‐649 expression was negatively associated with MALT1 expression in HSV‐1‐infected HeLa cells. Taken together, this present study indicates that miR‐649 promotes HSV‐1 replication through regulation of the MALT1‐mediated antiviral signaling pathway and suggests a promising target for antiviral therapies. J. Med. Virol. 89:1069–1079, 2017 . © 2016 Wiley Periodicals, Inc.