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Complete genome sequence of a KI polyomavirus isolated from an otherwise healthy child with severe lower respiratory tract infection
Author(s) -
Dehority Walter N.,
Eickman Megan M.,
Schwalm Kurt C.,
Gross Stephen M.,
Schroth Gary P.,
Young Stephen A.,
Dinwiddie Darrell L.
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24706
Subject(s) - genome , virology , biology , gene , virus , whole genome sequencing , genetics
Unbiased, deep sequencing of a nasal specimen from an otherwise healthy 13‐month‐old boy hospitalized in intensive care revealed high gene expression and the complete genome of a novel isolate of KI polyomavirus (KIPyV). Further investigation detected minimal gene expression of additional viruses, suggesting that KIPyV was potentially the causal agent. Analysis of the complete genome of isolate NMKI001 revealed it is different from all previously reported genomes and contains two amino acid differences as compared to the closest virus isolate, Stockholm 380 (EF127908). J. Med. Virol. 89:926–930, 2017 . © 2016 Wiley Periodicals, Inc.