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Human papillomavirus as a favorable prognostic factor in a subset of head and neck squamous cell carcinomas: A meta‐analysis
Author(s) -
Liu Hongwei,
Li Jintao,
Zhou Yubai,
Hu Qin,
Zeng Yi,
Mohammadreza Mohammadzad Mehryar
Publication year - 2017
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.24670
Subject(s) - human papillomavirus , etiology , medicine , oncology , histopathology , head and neck , meta analysis , hpv infection , pathology , cancer , cervical cancer , surgery
Many epidemical and biological studies have proposed that human papillomavirus (HPV), primarily high‐risk HPV16/18, is an etiological factor for a subset of head and neck (HN) cancers. On that premise, we systematically reviewed relevant articles and improved the understanding of HPV‐related cancers. This article comprehensively described the characteristics of HPV‐associated HN tumors according to demography, histopathology, molecular biology, and prognosis. Meta‐analyses were conducted to combine the studies that reported the association between HPV status and these variables using Rev Man 5.0. The pooled results showed that HPV‐positive tumors were not only poorly differentiated (OR = 2.77, 95% CI: 2.3–3.32) and smaller (OR = 2.21, 95% CI: 1.75–2.8) but were also strongly associated with oropharynx (OR = 5.8, 95% CI: 4.01–8.38) and node involvement (OR = 2.77, 95% CI: 2.3–3.32). HPV‐related tumors showed significantly more p16 overexpression (OR = 34.55, 95% CI: 20.91–57.09) and less TP53 mutations (OR = 0.27, 95% CI: 0.18–0.41) than HPV‐negative tumors. The patients with HPV‐positive cancers had different clinical behaviors, such as a reduced risks of death (HR = 0.32, 95% CI: 0.29–0.36). This study supported the view point that HPV is a favorable indicator of prognosis and that HPV‐related HN tumors are distinct from traditional tumors. This etiological relationship could impact future strategies of diagnosis, prevention, therapy, and prognosis for this subset of patients. J. Med. Virol. 89:710–725, 2017 . © 2016 Wiley Periodicals, Inc.